Fast magnetic resonance imaging (MRI) of invasive lung aspergillosis in immunocompromised children: comparison with HRCT

European Congress of Radiology, Vienna, Avusturya, 28 Şubat - 04 Mart 2018, ss.345

Purpose: To compare the diagnostic accuracy of fast lung MRI with high

resolution computed tomography (HRCT) in immunocompromised children with

invasive pulmonary aspergillosis.

Methods and Materials: Twenty seven children (14 boy, 13 girl, mean age=

12.8; range age 5-17 years) with suspected invasive pulmonary aspergillosis

after chemotherapy and hematopoietic stem cell transplantation underwent 1.5

Tesla MRI and HRCT. Pulmonary MRI study protocol included T2 weighted

half-Fourier single-shot turbo spin echo (HASTE) and T1 weighted volumetric

interpolated breath hold examination (VIBE) sequences. The average MRI

scanning time was three minutes. Both the location and the type of lesion (halo

sign, air crescent sign, peribronchial consolidation, bronchopneumonia,

centrilobular and tree in bud nodules) were assessed on MRI and HRCT

blinded to patient’s data by two radiologists. Kappa test, sensitivity, specificity,

accuracy, positive and negative predictive values were used to determine the

compliance.

Results: The location of the lesion in HRCT were concordant with T2 HASTE

sequence (κw:0,550 p=0,0001) and T1 VIBE sequence (κw:0,550 p=0,0001)

corresponding to a negative predictive value of 100%, positive predictive value

of 95%, sensitivity of 100%, specificity of 40%, accuracy 95%. The type of

lesion in HRCT were concordant with T2 HASTE sequence (κw:0,447

p=0,0001) and T1 VIBE sequence (κw:0,442 p=0,0001) corresponding to a

negative predictive value of 33%, positive predictive value of 100%, specificity

of 100% and accuracy 93%.

Conclusion: According to our study; MRI is a fast, radiation free examination

for detecting of pulmonary invasive aspergillosis lesions with high accuracy

rate in immunocompromised children.