Pain mechanisms in chronic pancreatitis: of a master and his fire

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Demir I. E., Tieftrunk E., Maak M., Friess H., Ceyhan G.

LANGENBECKS ARCHIVES OF SURGERY, cilt.396, sa.2, ss.151-160, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 396 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s00423-010-0731-1
  • Dergi Adı: LANGENBECKS ARCHIVES OF SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.151-160
  • Anahtar Kelimeler: Chronic pancreatitis, Pain, Peripheral pancreatic neuropathy, Neural remodeling, Sensitization, Temporal summation, EEG, Spinal hyperactivity, PYLORUS-PRESERVING WHIPPLE, CELIAC PLEXUS BLOCK, SUBSTANTIA-GELATINOSA NEURONS, NERVE GROWTH-FACTOR, NEUROPATHIC PAIN, SENSORY NEURONS, HEAD RESECTION, ELECTROPHYSIOLOGICAL PROPERTIES, RANDOMIZED-TRIAL, FOLLOW-UP
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Unraveling the mechanisms of pain in chronic pancreatitis (CP) remains a true challenge. The rapid development of pancreatic surgery in the twentieth century, usage of advanced molecular biological techniques, and emergence of clinician-scientists have enabled the elucidation of several mechanisms that lead to the chronic, complicated neuropathic pain syndrome in CP. However, the proper analysis of pain in CP should include three main arms of mechanisms: "peripheral nociception," "peripheral/pancreatic neuropathy and neuroplasticity," and "central neuropathy and neuroplasticity."