Early Atherosclerosis Exhibits an Enhanced Procoagulant State


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Borissoff J. I. , Heeneman S., Kilinc E., Kassak P., Van Oerle R., Winckers K., ...More

CIRCULATION, vol.122, no.8, pp.821-843, 2010 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 122 Issue: 8
  • Publication Date: 2010
  • Doi Number: 10.1161/circulationaha.109.907121
  • Journal Name: CIRCULATION
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.821-843
  • Keywords: atherosclerosis, hypercoagulability, immunohistochemistry, plaque, thrombosis, FACTOR PATHWAY INHIBITOR, CALIBRATED AUTOMATED THROMBOGRAM, PROTEASE-ACTIVATED RECEPTOR-1, TISSUE FACTOR, THROMBIN GENERATION, PLAQUE STABILITY, COAGULATION, INJURY, MICE, HYPERCOAGULABILITY

Abstract

Background-Thrombin generation in vivo may be important in regulating atherosclerotic progression. In the present study, we examined for the first time the activity and presence of relevant coagulation proteins in relation to the progression of atherosclerosis.