The melatonin MT2 receptor is involved in the anti-apoptotic effects of melatonin in rats with type 2 diabetes mellitus

YAPIŞLAR H., HACIOSMANOĞLU E., Sarioglu T., Ekmekcioglu C.

TISSUE & CELL, vol.76, 2022 (SCI-Expanded, Scopus) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 76
  • Publication Date: 2022
  • Doi Number: 10.1016/j.tice.2022.101763
  • Journal Name: TISSUE & CELL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: T2DM, Apoptosis, Melatonin, MT2, Luzindole, Experimental diabetes mellitus, MITOCHONDRIAL DYSFUNCTION, OXIDATIVE STRESS, INSULIN-RESISTANCE, NICK TRANSLATION, ADIPOSE-TISSUE, RISK-FACTORS, CELL-DEATH, ANTIOXIDANT, OBESITY, PROTEINS
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Type 2 diabetes mellitus (T2DM) is a widely prevalent chronic disease and risk factor for several other diseases, such as cardiovascular diseases, neuropathy, nephropathy, and retinopathy. Apoptosis is a homeostatic mechanism to maintain cell numbers at a certain level in tissues. Chronic high blood glucose levels might lead to mitochondrial dysfunction and trigger undesirable apoptosis in T2DM. The pineal hormone melatonin has been shown to regulate apoptosis. The aim of this study was to investigate the impact of the melatonin MT2 receptor in the role of melatonin to prevent undesirable apotosis in different tissues of diabetic rats.