TC-99m MIBI spect imaging in patients with lung carcinoma: Is it a functional probe of multidrug resistance genes?

Ak I., Guelbas Z., Ocak S., Kaya E., Alatas F., Vardareli E., ...Daha Fazla

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, cilt.31, sa.5, ss.795-799, 2007 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 5
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1097/rct.0b013e318033dee0
  • Dergi Adı: JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.795-799
  • Anahtar Kelimeler: lung carcinoma, Tc-99m MIBI, Pgp, MRP1, LRP, HEXAKIS 2-METHOXYISOBUTYL ISONITRILE, MAJOR VAULT PROTEIN, P-GLYCOPROTEIN, CELL-LINES, MRP GENE, BREAST-CANCER, EXPORT PUMP, EXPRESSION, MEMBRANE, MDR
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Objective: Multidrug-resistance (MDR) phenotype concerns altered membrane transport that results in lower cell concentrations of cytotoxic drug in many cancer types, including lung cancer, and is related to the overexpression of a variety of proteins that act as adenosine triphosphate-dependent extrusion pumps. Tc-99m Sestamibi (MIBI) is a transport substrate for P-glycoprotein (Pgp) pump. In this study, we assessed the uptake and clearance of technetium-99m-2-hexakis 2-methoxyisobutylisonitrile (Tc-99m MIBI) from the tumor and its correlation with messenger RNA (mRNA) levels of Pgp, MDR-associated protein (MRP1), and lung resistance protein (LRP) in lung carcinoma.