Do recurrent febrile convulsions decrease the threshold for pilocarpine-induced seizures? Effects of nitric oxide


Gulec G., Noyan B.

DEVELOPMENTAL BRAIN RESEARCH, cilt.126, sa.2, ss.223-228, 2001 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 126 Sayı: 2
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0165-3806(01)00098-0
  • Dergi Adı: DEVELOPMENTAL BRAIN RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.223-228
  • Anahtar Kelimeler: pilocarpine, susceptibility, seizure, rat, HYPERTHERMIA-INDUCED SEIZURES, TEMPORAL-LOBE EPILEPSY, STATUS EPILEPTICUS, LONG-TERM, RAT, SUSCEPTIBILITY, CHILDHOOD, GLUTAMATE, RESISTANT, SYSTEM
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

The aim of the study was to determine whether (1) number of febrile convulsions is a predictor of development of temporal lobe epilepsy, (2) the susceptibility of rats to pilocarpine-induced seizures is increased due to febrile convulsions and (3) nitric oxide is a mediator in the pathogenesis of febrile convulsions. Rat pups were exposed to single or multiple hyperthermic seizures. Subconvulsant doses of pilocarpine (100 mg/kg and 150 mg/kg) were injected intraperitoneally to these rats at 60-70 days of age. Also L-arginine was applied to some rats before a single hyperthermic seizure. We found that risk of future epilepsy increases parallel to the number of febrile convulsions and nitric oxide does not have a pathogenetic role at given doses. (C) 2001 Elsevier Science B.V. All rights reserved.