The impact of neoadjuvant therapy on the histopathological features of pancreatic ductal adenocarcinoma - A systematic review and meta-analysis

Schorn S., Demir I. E., Reyes C. M., Saricaoglu C., Samm N., Schirren R., ...Daha Fazla

CANCER TREATMENT REVIEWS, cilt.55, ss.96-106, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 55
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.ctrv.2017.03.003
  • Dergi Adı: CANCER TREATMENT REVIEWS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.96-106
  • Anahtar Kelimeler: Neoadjuvant chemoradiotherapy, Neoadjuvant chemotherapy, Pancreatic cancer, Pathology, Systematic review, Meta-analysis, LONG-TERM SURVIVAL, LYMPH-NODE RATIO, PREOPERATIVE CHEMORADIATION, NEURAL INVASION, CANCER, CHEMORADIOTHERAPY, PANCREATICODUODENECTOMY, RESECTION, CHEMOTHERAPY, RECURRENCE
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Background: Due to increased rates of curative tumor resections exceeding 60% after FOLFIRINOX-treatment, neoadjuvant therapy/NTx is increasingly recognized as an effective therapy option for down staging borderline or locally advanced pancreatic ductal adenocarcinoma/PDAC. Yet, the effects of NTx on the common histopathological features of PDAC have not been systematically analysed. Therefore, the aim of the current study was to assess the impact of NTx on relevant histopathological features of PDAC.