Tryptase potentiates enteric nerve activation by histamine and serotonin: Relevance for the effects of mucosal biopsy supernatants from irritable bowel syndrome patients

Ostertag, D.; Annahazi, A.; Krueger, D.; Michel, K.; Demir, I.; Ceyhan, GÜRALP; Zeller, F.; Schemann, M.

doi:10.1111/nmo.13070

Tryptase potentiates enteric nerve activation by histamine and serotonin: Relevance for the effects of mucosal biopsy supernatants from irritable bowel syndrome patients

Atıf İçin Kopyala

Ostertag D., Annahazi A., Krueger D., Michel K., Demir I. E., Ceyhan G. O., ...Daha Fazla

NEUROGASTROENTEROLOGY AND MOTILITY, cilt.29, sa.9, 2017 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 29 Sayı: 9
Basım Tarihi: 2017
Doi Numarası: 10.1111/nmo.13070
Dergi Adı: NEUROGASTROENTEROLOGY AND MOTILITY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Background: We previously showed that mucosal biopsy supernatants from irritable bowel syndrome patients activated neurons despite low concentrations of tryptase, histamine, and serotonin which individually would not cause spike discharge. We studied the potentiating responses between these mediators on excitability of enteric neurons.