Akademik Veri Yönetim Sistemi
Özpınar A. (Yürütücü), Serdar M. A., Serteser M., Kilercik M., Çetiner M.
Diğer Ülkelerden Üniversiteler Tarafından Desteklenmiş Proje, 2024 - 2025
Oxidative
stress and inflammation play central roles in the immunopathogenesis of
COVID-19. In this study, the protective
effects of carotenoids, retinol, and vitamin E as antioxidants and
anti-inflammatory were investigated for their potential to distinguish COVID-19
and its severity. 44 COVID-19 patients, and 39 healthy controls
categorized into three groups based on severity were analyzed. Carotenoids,
vitamin E, vitamin A Retinol binding-protein 4 (RBP4)
and transthyretin (TTR), total blood cells,
clinical chemistry and inflammation markers were evaluated and statistically
analyzed. Concentrations of γ-tocopherol, α-tocopherol, retinol, total vitamin
A, lutein, total carotenoids, TTR, and inflammatory markers were significantly
lower in COVID-19 patients compared to healthy controls. Multivariate
regression analysis identified three independent parameters that effectively
distinguished COVID-19 patients from healthy controls: RBP4/total vitamin A,
γ-tocopherol and ferritin. This study shows that carotenoids, retinol and
vitamin E were inadequate in distinguishing COVID-19 disease severity, however,
along with the independent predictive values of the RBP4/total vitamin A ratio,
γ-tocopherol, and ferritin, these antioxidants were significantly reduced in
COVID-19 patients compared to the control group, thereby demonstrating their
potential as reliable biomarkers for distinguishing COVID-19.