Akademik Veri Yönetim Sistemi
Tezin Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Acıbadem Mehmet Ali Aydınlar Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Temel Bilimler Bölümü, Türkiye
Tezin Onay Tarihi: 2022
Tezin Dili: İngilizce
Öğrenci: Emre Burak Erkal
Danışman: Deniz Demirhan
Özet:
In recent years, the development of therapeutic
monoclonal antibodies (mAbs) has gained considerable importance, and these
molecules have become increasingly important in the worldwide biotechnological
drug market. Many biotechnology companies are investing in monoclonal antibody
production for treatment of various diseases. Bioreactor production and
purification are the two major steps in the manufacturing of these antibodies. Current purification methods used for these
molecules are extensively discussed in this review. The basic recovery and
purification processes for monoclonal antibodies such as cell harvesting,
Protein A affinity chromatography, and additional polishing steps are all
studied in this thesis.